OXIPENAM-1000 Injection

Meropenem is a new beta-lactam antibiotic belonging to the carbapenem class used to treat a variety of bacterial infections. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. Meropenem exerts its bactericidal action by binding to penicillin-binding proteins (PBPs) in the bacterial cell wall and inhibiting peptidoglycan cross-linking associated with cell wall synthesis, which ultimately leads to cell death. The spectrum of action includes many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. The overall spectrum is similar to that of imipenem, although meropenem is more active against Enterobacteriaceae and less active against Gram-positive bacteria. It works against extended-spectrum β-lactamases, but may be more susceptible to metallo-β-lactamases. Meropenem is frequently given in the treatment of febrile neutropenia. This condition frequently occurs in patients with hematological malignancies and cancer patients receiving anticancer drugs that suppress bone marrow formation. It is approved for complicated skin and skin structure infections, complicated intra-abdominal infections and bacterial meningitis.