Glucosamine is a chemical compound that occurs naturally in both human and animal tissues. In humans, it helps form cartilage and is commonly used as a dietary supplement to treat joint disorders like osteoarthritis. Glucosamine helps develop tissues that are crucial for proper joint function. While more studies are necessary, some research indicates that glucosamine supplements may protect your joints from damage. Diacerein is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (pain, stiffness and swelling in the joints). Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models. Methylsulfonylmethane (MSM) is a sulfur-containing compound found in plants, animals, and humans. It can also be made in a lab into a dietary supplement, which is used widely in alternative medicine. MSM is often used by people looking for a natural way to relieve joint pain, reduce inflammation, and boost immunity. MSM is an analgesic, antiinflammatory, and blood vessel dilator. In OA, MSM works by reducing inflammation and blocking the pain response in nerve fibers.