The combination of Silver sulfadiazine and Chlorhexidine primarily used to treat burns (second-and third-degree) and prevent skin infections. Silver Sulphadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a broad-spectrum activity against many gram-negative and gram-positive bacteria, anaerobes, and some yeast. Silver sulfadiazine acts on the cells membrane and cell wall of microorganisms to produce bactericidal effect by inhibit the production of folic acid (a vitamin) necessary for bacteria to multiply and increase in numbers. Silver sulfadiazine is used to prevent and treat infections of second-and third-degree skin burns. It has a bactericidal action against organisms found in burns. Chlorhexidine gluconate is an antiseptic and disinfectant which works against a wide range of bacteria on the skin by stopping them growing and spreading. It kills infectious microorganisms and effectively cleans out cuts, wounds, and burns to prevent them from getting infected.