Racecadotril also known as acetorphan, is an antidiarrheal medication which acts as a peripheral enkephalinase inhibitor. Unlike other opioid medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect. it reduces the secretion of water and electrolytes into the intestine. Racecadotril is used for the treatment of acute diarrhea in children and adults and has better tolerability than loperamide, as it causes less constipation and flatulence. Several guidelines have recommended racecadotril use in addition to oral rehydration treatment in children with acute diarrhea. Racecadotril has a faster time to cessation of diarrhoea and fewer adverse effects compared to loperamide. Moreover, racecadotril has no contraindications and can be safely used in patients with dysentery or bacterial enterocolitis.