Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with site specific action and can use long term for the treatment of chronic rheumatic disorders as well as acute inflammatory conditions. Rabeprazole is a proton pump inhibitor used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. It may also be used along with other medications to eliminate Helicobacter pylori. Effectiveness is similar to other proton pump inhibitors (PPIs). Aceclofenac + Rabeprazole is safer choice for patients in long term treatment of Acute & Chronic painful conditions without GI disturbance.